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Hodgkin's disease, lymphocyte predominant type
Clinical features: Occurs at all ages, adults > children, males > females. Involves peripheral lymph nodes with sparing of mediastinum. Usually localized at diagnosis. Long survival rates for localized cases. Late relapses more common than other types of Hodgkins. May be associated with large B-cell lymphoma.
Pathology: predominantly lymphocytes with or without histiocytes, plasma cells, eosinophils and neutrophils rare. nodular pattern with or without diffuse areas. atypical cells with lobulated vesicular nuclei, designated L&H (lymphocyte and/or histiocyte) or popcorn cells. usually no diagnostic Reed-Sternberg cells.
Immunophenotype: atypical cells
- CD45 +
- B-cell antigen (CD19, CD20, CD22, CD79a) +
- CDw75 +
- EMA +/-
- CD15 -
- CD30 -/+
- Ig usually -
Genetics:
- Ig & TCR genes germline
- EBV -, most cases
Interactions
disease interactions
General
Hodgkin's disease (Hodgkin's lymphoma)
References
- Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML,
Delsol G, De Wolf-Peeters C, Falini B, Gatter KC, et al.
A revised European-American classification of lymphoid
neoplasms: a proposal from the International Lymphoma Study
Group.
Blood. 1994 Sep 1;84(5):1361-92. Review.
PMID: 8068936